Antidepressants may not work – report

Posted on January 22, 2008 

Antidepressants may not work – report

Antidepressants may not work - report

Patients and doctors alike may have received some fuzzy truth about the effectiveness of antidepressant medication.

According to a report in The Wall Street Journal, many studies have found that best-selling antidepressants like Wyeth’s Effexor and Pfizer’s Zoloft may have little or even no effect on patients. Many of those studies, though submitted to the Food and Drug Administration, were left unpublished.

Both Pfizer (PFE, Fortune 500) and Wyeth (WYE, Fortune 500) told The Wall Street Journal that they will disclose all study results, but they will not necessarily publish them in medical journals. The FDA does not require pharmaceutical companies to publish the studies that they sponsor, which leaves many studies unpublished. Separately, 74 studies involving 12 antidepressant drugs were submitted to the FDA between 1987 and 2004, 38 of which the FDA called “positive.” Though all but one of the “positive” studies were published, only 14 of the 36 “negative” studies were printed in medical journals.

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